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Title   진행성 비소세포성 폐암에서 FEP ( 5 - Fluorouracil , Etoposide , Cisplatin ) 3 제 병용 약물요법의 제 2 상 임상시험 ( Phase 2 Trial of 5 - FU , Etoposide , Cisplatin ( FEP ) Combination Chemotherapy for Unresectable Non - Small Cell Lung Cancer )
Publicationinfo   1991 Jan; 023(01): 120-131.
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Abstract   We initiated a phase II trial for advanced, unresectable non-small cell lung cancer (NSCLC). The therapy consisted of 2 cycles of 5-FU (1000 mg/m i.v, day 1-3), etoposide (100 mg/m i.v, day 1-3), and cisplatin (80 mg/m' i.v, day 4) given every 3wks. After the initial 2 cycles of chemotherapy, the response was evaluated. If the response was more than stable state, the patients with stage III were received radiotherapy consisting of 5500-6500 cGy/5-6wk, and the patients with stage IV continued same chemotherapy every 3 weeks. The following results were obtained; 1) There were 17 patients (56.7%) with partial remission (PR), 11 patients (36.7%) with stable disease, and 2 patients (6.6%) with progressive disease after initial chemotherapy. There were 1 patient (8.3%) with complete remission and 9 patients (75.0%) with partial remission and 1 patient (8.3%) with disease progression after completion of chemo-radiotherapy in stage III patients. The overall response duration was 4.0 months (range; 1-20 months). 2) The response rate by the initiaf FEP chemotherapy was not affected by the discrepancy in sex, age, and stage.
저 자   최진혁(Jin Hyuk Choi),정현철(Hyun Cheol Chung),김동립(Dong Lip Kim),오제열(Je Yol Oh),장준(Joon Chang),고은희(Eun Hee Koh),김주항(Joo Hang Kim),노재경(Jae Kyung Roh),김병수(Byung Soo Kim),김성규(Seong Kyu Kim),이원영(Won Young Lee),김귀언(Gwi Eon Kim),노준규(Jun Kyu Loh)